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Death without caspases, caspases without death.
Apoptosis is a conserved cell-death process displaying characteristic morphological and molecular changes including activation of caspase proteases. Recent work challenges the accepted roles of these proteases. New investigations in mice and the nematode Caenorhabditis elegans suggest that there could be caspase-independent pathways leading to cell death. In addition, another type of cell death...
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When I was a kid I wanted to be the kind of person who can crash land in the desert and walk for days to safety; the loyal adventurer who won’t give up searching the mountains for a friend even when everyone else is exhausted. Then I got a diagnosis of type 1 diabetes. Life with type 1 is manageable, but it’s hard work to be adventurous and it’s impossible to be completely spontaneous. If I wer...
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T he present health care environment conflicts with the values in· ternalized by many clinicians Patient care seems to be subordinated to a set of rules governing the length of hos· pitalization. The decision makers in health care seem to take a clerical rather than a clinical perspective. As one frustrated clinician exclaimed, "Forget TLC; it's DRGs that count." Although the feelings in this t...
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We show that if a cellular automaton in two or more dimensions supports growing \ladders" which can turn or block each other, then it can express arbitrary Boolean circuits. Then the problem of predicting the CA for a nite amount of time becomes P-complete, the question of whether a nite connguration grows to innnity is P-hard, and the long-term behavior of initial conditions with a periodic ba...
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Eczematous dermatitis comprises a heterogenous group of inflammatory skin diseases characterized by a typical morphological reaction pattern. In the acute stage, the typical clinical features include itching, redness, papules, and vesicles associated with exudation. The two most frequent reasons for an eczematous reaction are atopic dermatitis (AD) and allergic contact dermatitis (ACD). Althoug...
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ژورنال
عنوان ژورنال: BMJ
سال: 1982
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.284.6312.345